Endocrine Abstracts

BackgroundIntravenous levothyroxine (IVT4) is FDA-approved for the treatment of myxedema coma (ME). We noticed that at our hospital, IVT4 is administered more frequently than expected.Aim of studyTo assess the extent of IVT4 administration, the indications for such a treatment, and its outcome at a tertiary facility.MethodsA retrospective study of IVT4 administere...

Serum total cortisol has been linked to increased mortality in patients with Covid-19, but its reliability in critically ill patients is limited. We examined the association between serum free cortisol (SFC) levels and clinical outcomes in patients hospitalized with Covid-19 between 5/5/2020 and 1/3/2021 in our institution. Methods: SFC was measured in blood samples collected at patient’s admission, prior to any medical treatment. Patients’ fil...

Background: Among the various ethnicities in the Israeli mosaic, the Ethiopian community is the most recently settled, with an immigration that started less than 40 years ago. Largely young, this 160,000-member community comprises nonetheless about 25,000 persons 50 years or older, virtually all born in Ethiopia. Despite this growing aging population, there is no knowledge regarding osteoporotic fractures in this unique East African ethnic group, not even from data originating...

Background and aim of study: Endocrinologists play a central role in the gender affirming process that transgender people chose to undergo, and may be ill-prepared to recognize and manage psychologic difficulties that accompany gender dysphoria. We sought to characterize the patient population currently under our care with respect to their mental health, and to address the question of possible differences between transwomen (TW) and transmen (TM).Methods...

Background: True Cushing’s syndrome (CS) is an exceedingly rare condition, thus to avoid unnecessary and costly testing, a diagnostic investigation should only start based on solid clinical suspicion. The current obesity epidemic has become a hurdle in discriminating subjects at real risk for CS from those with the metabolic syndrome. Moreover, many CS patientsrecently diagnosed do not fit the typical clinical profile of ‘at risk subjects’.<p class="abste...

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors decrease the degradation of low–density lipoprotein (LDL) receptors, thereby increasing the removal of LDL particles from the blood and significantly reducing LDL cholesterol levels by an average of 65%. Blom et al. showed changes in vitamin E, adrenocorticotropic hormone (ACTH), cortisol, total testosterone, and estradiol in EVOLOCUMAB (PCSK9 inhibitor)–treated patients 1. Ther...

Background: The standard approach for Gender-Affirming Hormone Therapy (GAHT) of transgender women (TW) in Israel is oral estradiol (OE) combined with the potent anti-androgen cyproterone acetate (CA). Recently, many of our non-binary patients have requested sublingual estradiol (SLE) without CA, under the unproven belief it preserves erectile function, and does not induce depression. Preliminary data in a few subjects, who self-practiced this approach, suggested it also maint...

Background: Although successful pregnancies carried by transgender men have been reported, long-term effects of testosterone therapy on fertility remain unknown.Aims: To study markers of ovarian reserve during testosterone therapy.Methods: Prospective open-label study of transgender men prior and during treatment with testosterone. Sampling was conducted at baseline and 12 months after treatment initiation.Ma...

Background: Various components of metabolic syndrome (MS) significantly increase the risk of thyroid cancer (TC). Moreover, thyroid cancer survivors (TCS) are at increased risk of new components of MS (MSC). The role of thyroid function in this context has not yet been determined. We investigated changes in selected MSC and their association with thyroid function during a two-year follow-up among TCS.Materials and Methods: This retrospective, nested case...

Background: The BSRTC aimed to standardize thyroid cytopathology reporting while enabling stratification of risk of malignancy (ROM) in thyroid nodules. Observational studies have demonstrated varying ROM for the Bethesda III and IV categories, further affected by the recent exemption of NIFTP. Finally, molecular testing is becoming a reasonable alternative for evaluating ROM in categories III and IV.Objective: To retrospectively establish the use of Bet...